Stem Cell therapy in mouse model of LGMD2I

Drs. Casey Childers & David Mack

University of Washington (Seattle, WA)

 

Project Summary:

The objective of this project is to test the efficacy of stem cell therapy in improving muscle function of the mouse model of LGMD2I. Induced Pluripotent Stem (iPS) cells derived from normal control mice will be induced to become muscle progenitor cells and will be transplanted into the muscles of FKRP-mutant mice. Transplanted mice will be analyzed for improvement in function and muscle strength. This is the mouse stem cells counter-part of the stem-cell project that we are currently funding at Dr. Perlingeiro’s lab at the University of Minnesota.